Correlation between thyroid function tests and lipid profile in patients of primary hypothyroidism

Aim: to correlate between thyroid function tests and lipid profile in patients of primary hypothyroidism. methods: eighty subjects (both males and females) were recruited for this study. patient group (g) (patients of primary hypothyroidism) was of 40 subjects,while the remaining 40 subjects included were healthy subjects constituting control group (cg.). 40 subjects diagnosed as patients of primary hypothyroidism (tsh <10μiu) with age range 18-40 years were selected. 40 age,body mass index (bmi) and sex matched euthyroid subjects were selected as controls. all the subjects were having body mass index value between 20 and 25kg/m2. all subjects were having the same socioeconomic status,dietary habits,life style and physical activity. this was evaluated through detailed interviews. the subjects having diabetes mellitus and ischaemic were excluded. the individuals who were on any drug therapy that could alter lipid metabolism and thyroid function were also excluded. no female was postmenopausal. subjects with body mass index value above 25 kg/m 2 were not recruited. results: in patients of primary hypothyroidism highly significant positive correlation was found between tsh and tc (r=0.535). in patients of primary hypothyroidism highly significant positive correlation was found between tsh and ldlc (r=0.4712). in patients of primary hypothyroidism highly significant positive correlation was found between tsh and tag (r=0.5862). in patients of primary hypothyroidism,nonsignificant correlation was found between tsh and hdlc (r=0.0480). conclusion: in conclusion our results have proved the beneficial effects of l-thyroxine on the lipid profile of patients of primary hypothyroidism. this study has showed the decreased tc,ldlc and tag levels after treatment. the ldlc/hdlc ratio also decreased after treatment.