Pharmacological management of postpartum hemorrhage by giving P/R misoprostol after failure of syntocinon

Aim: to determine the effect of one tablet misoprostol 200mg in management of postpartum hemorrhage due to uterine atony after failure of syntocinon. study design: obsinational descriptive study. place and duration of study: study was conducted in nishtar hospital multan in 1 year. method: 100 cases of post partum hemorrhage were taken during year and effect of 200mcg misoprostol was analyzed. results: 100 cases of pph were included in this study whether they were delivered vaginally or by c. section. post partum hemorrhage is most commonly seen in late reproduction age group and with high parity 83%. patients belong to prolonged duration of labour. 58% of normal vaginal deliveries went into uterine atony 27% being to mild bleeding 58% developed moderate bleeding and 15% of severe bleeding 52% of mild bleeding and 36% patient of moderate bleeding showed best results of misoprostol 200mcg without side effect. only 12% of severe bleeding achieved good results by giving misoprostol. conclusion: prevention of post partum hemorrhage by giving awareness about this serious entity and magnitude of reduction in amount of bleeding in our trial suggest the use of misoprostol. it needs no i/v access and stability at high temperature.