Comparison of serum anti-mullerian hormone and antral follicle count as predictor of infertility in females of Karachi

Background: fertility in women is determined by ovarian reserve,which is currently defined as the number and quality of the follicles left at any moment in the ovary. antimullerian hormone (amh),has been suggested as a representative of the ovarian reserve because in females,amh is exclusively produced by granulosa cells of preantral (primary and secondary) and small antral follicles. aim: to estimate serum level of antimullerian hormone in study subjects and to compare it with antral follicle count (afc) as a predictor of infertility. methods: a comparative cross sectional study was conducted on total ninety female subjects (sixty infertile and thirty fertile) recruited conveniently through outpatient department of two tertiary care hospitals of karachi. serum amh of each participant was recorded on day 3 of menstrual cycle and on the same day antral follicle count was measured through transvaginal ultrasonography. results: both the amh and afc were reduced in infertile group as compared to control but reduction in mean amh levels with age was found statistically significant than afc. conclusion: it was concluded that as compared to afc,amh is considered as more suitable hormone,to identify the potential reproductive capacity of a female.