Relationship of systemic blood pressure,intraocular pressure and ocular perfusion pressure

Aim: to study the relationship of systemic bp with intraocular pressure and ocular perfusion pressure study design: cross sectional study place: combined military hospital lahore and arif memorial teaching hospital lahore. methods: patients reporting in opd were included in the study. patient with cataract,glaucoma and eye trauma were excluded from the study. intraocular pressure was measured in both eyes by applanation tonometry. systolic blood pressure (sbp) and diastolic blood pressure (dbp) measurements were performed and mean arterial blood pressure (mabp) and mean ocular perfusion pressure (mopp) were calculated. data was analyzed by spss version 18. pearson correlation coefficient was calculated to identify the relation of systemic blood pressure with iop and mopp. linear regression analysis was run with iop and mopp as the dependent variable and blood pressure,age and gender as the independent variables. p value <.05 was considered significant. results: a total of 120 patients were included in the study,63(52.5%) were male and 57(47.5%) were females. on running pearson correlation coefficient iop right eye was significantly associated with sbp(p.011),dbp (p.045),mabp(p.015) and pulse pressure (p.036).similarly iop lt eye was strongly associated with sbp(p.001),dbp (p.031),mabp (p.003) and pulse pressure (p.002).age and iop had a positive correlation but it was not statistically significant(p.053).on linear regression analysis iop was strongly associated with mabp (p.015),sbp (p.011),dbp (p.045) and pulse pressure (p.036) and corresponding regression coefficients were .059,.039,.06 and .045 per mm of hg increase in iop per mm hg increase in mabp,sbp,dbp and pulse pressure,respectively. similarly,mopp was strongly associated with mabp (p<.001),sbp (p<.001),dbp (p<.001) and pulse pressure(p<.001) and corresponding regression coefficients were .607,.351,.699 and .045 per mmhg increase in mopp per mm hg increase in mabp,sbp,dbp and pulse pressure,respectively. conclusion: intraocular pressure and mean ocular perfusion pressure is strongly associated with mean arterial blood pressure,systolic blood pressure,diastolic blood pressure and pulse pressure. as compared to intraocular pressure,the mean ocular perfusion pressure has more significant and powerful correlation with blood pressure.