Safety of low molecular weight heparin and unfractioned heparin in prevention of venous thromoboembolism (VTE)

Aim: to compare the safety of low molecular weight heparin and unfractionated heparin in prevention of vte in surgical patients study design: randomized control trial. place: surgical department,pof hospital wah cantt,a tertiary care teaching hospital affiliated with wah medical college. duration of study: from 1st january 2013 to 1st july 2014. methodology: two hundred cases of moderate risk surgical patients for vte were selected by nonprobability consecutive sampling and divided into two groups a & b. group a: received low molecular weight heparin. group b: received unfractionated heparin. patients in both the groups were monitored for bleeding from the surgical wound at 1st,2nd and 3rd postoperative day and the data was analyzed with spss version 17. results: there were total 200 cases operated under general anesthesia of more than 30 minutes duration having their base line investigations hemoglobin,platelet count and aptt in optimum range. bleeding from the surgical wound was observed in 2 patient of group a and 10 patients of group b. conclusion: low molecular weight heparin is safer than unfractioned heparin in prophylaxis of venous thromboembolism.