Comparison of serum level of alanine amino transferase at 12 weeks and 24 weeks after the start of interferon therapy in chronic hepatitis C patients

Aim: to compare serum level of alanine aminotransferase in term of normalization at 12 weeks versus 24 weeks after start of interferon therapy in chronic hepatitis c patients. settings: this quasi-experimental study was conducted at the department of pathology,quaid-e-azam medical college/bahawal victoria hospital,bahawalpur from january 2013 to june 2013. a total of 223 patients were enrolled to compare serum level of alanine aminotransferase in term of normalization at 12 weeks versus 24 weeks after start of interferon therapy in chronic hepatitis c patients. results: in our study,majority of the patients were between 41-60 years i.e. 113(50.67%3),mean and sd was calculated as 44.65±4.21 years,119(53.36%) male and 104(46.46%) were females,comparison of serum level of alanine aminotransferase in term of normalization at 12 weeks vs 24 weeks after start of interferon therapy in chronic hepatitis c patients was done which shows 196(87.89%) in pts at 12 weeks of treatment while 213(95.52%) in patients at 24 weeks of treatment had normal alanine aminotransferase levels,it shows a sig. difference by calculated p value 0.03. conclusion: normalization of alanine aminotransferase is found significantly higher at 24 weeks of therapy than 12 weeks.