Effects of nigella sativa on HDL-c & body weight

Hyperlipidemia with increased body weight are main cause of consideration on cad. these pathological states eventually leading to development of metabolic syndrome are leading cause of morbidity and mortality throughout the world. various drug groups and regimen are being used to handle these problems but none is absolute satisfactory due to their widespread side effects and low compliance. conventional use of nigella sativa for many diseases are now emerging in allopathic discipline of healthcare to cure various diseases with good compliance with least side effects. this study was conducted in lipid research centre,pakistan institute of cardiology,lahore,pakistan,from october to december 2013. study period was one month. sixty male and female hyperlipidemic patients age range from 20 to 70 years were included in the research with written explained and approved consent. all patients were divided in two equal groups. in group-a,30 patients were advised to take two spoons of kalonji after breakfast for the period of four weeks. in group-ii,30 hyperlipidemic patients were advised to take placebo capsules after breakfast everyday for the period of four weeks. at the end of research work,mean values of all parameters with ±sd were analyzed statistically using paired 't' test. these results were compared with placebo therapy and observed that both parameters showed highly significant change,with p-value <0.001. we concluded from these results that kalonji is very effective herbal drug to increase hdl-c and decrease body weight.