Frequency of hematological disorders in children diagnosed on bone marrow examination

Aim: to determine the frequency of hematological disorders in children diagnosed on bone marrow examination.methods: a total of three hundred patients suspected of different haematological disorders were included in the study based on their history and clinical examinations. it was a descriptive case series study conducted at department of haematology and transfusion medicine of the children hospital and the institute of child health,lahore during august 9,2007 to may 28,2009. haematological disorders were diagnosed on bone marrow aspiration morphology and trephine biopsies.results: of the 300 patients,45.6% were found to have acute lymphocytic leukemia,10% were found to have acute myeloid leukemia,13.3% patients had aplastic anemia,10% had idiopathic thrombocytopenic purpura,9% had storage diseases and 3.3% patients had infiltration of bone marrow by round blue cell tumors. almost 9% of patients had other haematological disorders which included megaloblastic anemia,pure red cell aplasia,juvenile myelomonocytic leukemia,chronic myeloid leukemia,hemophagocytic syndrome and congenital dyserythropoietic anemia.1% of patients were diagnosed to have histiocytic sarcoma and myelofibrosis.conclusion: acute leukemia is quite frequent in pakistani children. all/l1 being the predominate type affecting children under 5 years old. amongst aml,m4 is seen more frequently in children. this disorder is followed by aplastic anemia and idiopathic thrombocytopenic purpura. storage diseases are also common in children,and it mainly includes gauchers disease and neiman pick disease. other haematological disorders are less common and they include infiltration of bone marrow by round blue cell tumor,megaloblastic anemia,cml,jmml,cda and so on. © 2014 pakistan journal of medical and health sciences. all rights reserved.