A study of myeloperoxidase and lipid profile in obese individuals

Aim: to measure myeloperoxidase in obese subjects,who usually have deranged lipid profile,and to observe the association of myeloperoxidase with obesity as an early predictor of oxidative stress to prevent atherosclerotic cardiovascular diseases.results: obese group had a mean serum mpo level of 207.96 44.28ng/ml which was significantly (p<0.001) higher than the controls who had mean serum mpo level of 80.04±24.8ng/ml. serum cholesterol,triglycerides and ldl of obese group was significantly higher than the control group. mpo showed significantly (p<0.05) positive correlation (r=0.487) with age in the control group. mpo showed a significant positive correlation with cholesterol,triglycerides and ldl in the obese group.methods: twenty five obese subjects having a bmi ≥30kg/m2and 25 controls with a bmi ≤ 24.9 kg/m2,both males and females were taken.conclusion: the study concludes that serum mpo levels are raised in obese individuals. this indicates that mpo is associated with increased oxidative stress as in obesity. mpo is also significantly correlated with cholesterol,triglycerides and ldl. all these factors therefore indicate that obesity may be associated with increased risk of atherosclerosis. © 2014 pakistan journal of medical and health sciences. all rights reserved.