Comparative efficacy of sevelamer hydrochloride versus calcium acetate on bone biomarkers in patients with end stage renal disease on hemodialysis

Methods: this was a prospective,randomized,open label study,total 140 patients of esrd underwent two week washout period and were divided randomly into two groups,group a (received sevelamer) and group b (received calcium acetate) for 24 weeks. mean changes in the serum level of calcium phosphorus and intact pth were measured and compared.aim: to compare the effects of sevelamer and calcium acetate on biomarkers of bone turnover in patients of end stage renal disease (esrd).results: after 24 weeks of treatment there was significantly reductionof phosphorus in group a as compared with group b (-1.764mg/dl vs.1.0600 p=0.000). mean change in ipth was more in group b as compared with group a (-124.32pg/ml vs. -83.44 pg/ml,p=0.044). there is significant increase in serum calcium level in group b patients compared to group a (0.688mg/dl vs. -0.126 mg/dl,p=0.000).conclusion: sevelamer effectively reduces serum phosphorus with a lower incidence of rise in serum calcium level in dialysis population,although more reduction of ipth occurred in calcium acetate group. © 2014 pakistan journal of medical and health sciences. all rights reserved.