Carcinoma of breast: Role of hormone therapy pre-menopausal women according to receptors status in adjuvant setting

Aim: role of hormone therapy in pre-menopausal according to the receptors status with chemotherapy.methods: this interventional study was conducted at department of pathology shaikh zayed hospital,lahore from january 2010 to january 2013. fifty patients of breast cancers of females were included. all females of reproductive age,pre-menopausal with malignancy diagnosed by histopathology were included. the females of post-menopausal,benign breast lesion and carcinoma in situ were excluded. all patients were first fnac then mastectomy followed by chemotherapy fac 6-8 cycles and ac 4 + taxol 4. the hormone therapy timoxyfen 20 mg od were started according to the receptor status. after completion of treatment follow-up visits of patients were planned after every 3 months for 2 years and every 6 months for 3 years.results: the mean±sd between the age was 37.86±3.71 years. fourteen patients have positive lymph node involvement and all cases of ductal cell carcinoma. there were 39 patients of er,19 patients of pr and 29 patients of her2/neu status of positive cases. 32 patients were treated by fac 6 cycles and 18 patients were treated by ac 4 + taxol 4.conclusion: neoadjuvant chemotherapy is a well tolerated mode of treatment and leads to good local and systemic control of the disease. © 2014 pakistan journal of medical and health sciences. all rights reserved.