Serum lipoprotein (a) and symptomatic peripheral arterial disease in diabetic patients

Aim: to determine the association between levels of lipoprotein (a) concentration and peripheral arterial disease in diabetic patients. methods: in this case control study,159 diabetic patients were included. 53 subjects with peripheral arterial disease (pad) selected as cases and 106 subjects without pad selected randomly as control. among them,72 were males and 87 were females. inclusion criteria was age forty years and above and confirmed diabetics with minimum duration of 5 years and exclusion criteria was coronary artery disease (cad),raynaud's disease,patient with acute illness,patients taking niacin and estrogen replacement therapy. blood samples were taken after the written consent of participants. history was taken on prescribed performa. serum was separated and estimation of lp(a) and serum glucose were determined immediately. turbidometery immunoassay method was used for the detection of lp (a). results: there is decreased abi in group a when comparing with group b controls with significant difference. lp(a) in group a is increased as compared to group b. there is week negative correlation between lp(a) and abi. there is negative correlation between abi and age. conclusion: it is concluded that lipoprotein (a) has association with peripheral arterial disease but statistically non significant (p>0.05).