Improve healing in open haemorroidectomy with 0.2% GTN

Aim: to compare the efficacy of topical 0.2% glyceryl trinitrate vs. placebo on wound healing after open hemorroidectomy. methods: this randomized control trial was conducted in surgical unit i,nishtar hospital multan from may 2011 to october 2011. a total of 56 patients were included in this study. results: fifty six patients were included in the study which were divided into two groups (i.e.,gtn-28 and placebo=28). among them 40(71.4%) were male and 16(28.6%) were male. out of 56 patients,12 (21.4%) patients were in the age from 20-30 years,13(23.2%) within 31-30 years,16(28.6%) between the age 41-50 years and 15(26.8%) patients were in the age group from 51-60 years. as regards the grades of haemorrhoids,22(78.6%) patients from gtn group and 18(64.3%) patients from placebo group were in the grade-iii. while 6(21.4%) patients from gtn and 10(35.7%) patients from placebo group were in the grade-iv. incidence of headache was found in 8 28.6%) patients in gtn group and in (27.1%) patients in placebo group. conclusion: it is concluded from the study that gtn ointment enhances the healing of post hemorrhoidectomy wounds without significant side effects. also,gtn ointment had an effect to decreasing postoperative pain. however,as an analgesic,gtn ointment has no merit.