Haemoglobin electrophoresis pattern in normal siblings and beta thalassemia trait siblings of beta thalassemia major patients

Aim: to determine haemoglobin electropherogram in siblings of beta thalassemia major patients. a total of 200 subjects were included in the present study and divided into two equal groups. group ia with normal siblings of btm patients and ib with beta thalassemia trait (btt) siblings of btm patients. patients with history or diagnosis of any acute or chronic illnesses were excluded from the study. haemoglobin electrophoresis was performed. 5 ml of blood was drawn in edta containing tube and was used for haemoglobin electrophoresis. results/conclusions: out of 200 siblings of beta thalassemia major (btm) patients,156(78%) were diagnosed as beta thalassemia trait (btt). hba2 and hbf were increased in btt siblings (ib) as compared to normal siblings of btm patients (ia).