Comparison of surgical site infection rate in case of penetrating hollow viscus injury after perioperative antibiotics use for 24 hours versus 5 days

Aim: to compare surgical site infection rate in patients receiving i/v antibiotics for 24 hours versus those receiving for 5 days in penetrating abdominal hollow viscus injury. methods: this randomized control trial study was carried out at department of general surgery unit ii; jinnah hospital,lahore over a period of twelve months from 1st july 2014 to 30th june 2015. all subjects were selected from emergency department were divided into two groups by using alternate method (first patient give 24 hour antibiotics and second patient give 5 days' antibiotics). after informed consent all patients were given prophylactic broad spectrum i/v antibiotics. post operatively,patients were treated according to their groups. group a patients were administered two doses of i/v antibiotics while in group b patients were administered i/v antibiotics for 5 days. surgical site infection rate was compared in both groups. results: two hundred and twenty patients were randomly divided in two groups. only 25 patients (11.4%) out of 220 patients were having surgical site infection. 18 patients (16.4%) belonged to 24 hours antibiotic use group while 7(6.4%) were from 5 days antibiotic use group. the resultant difference was statistically significant (p value=0.01). younger age and male gender were more prone to surgical site infection in 24 hours antibiotic use group. conclusion: it is concluded that at current sample size we reject the null hypothesis that the rate of surgical site infection is same in patient with 24 hours use of intravenous antibiotics versus 5 days in penetrating abdominal hollow viscus injury.