Melatonin can restore the density of bone decreased by hyperthyroidism-induced osteoporosis

Background: hyperthyroidism is accompanied by increased rates of bone formation and resorption. melatonin through its free radical scavenging and antioxidant properties,impairs osteoclast activity and bone resorption in hyperthyroid state. aim: to study the effect of melatonin on bone density decreased during hyperthyroidism. duration of study: 01 november to 30th of january,2014-15. study design: randomized controlled trial. place of study: anatomy department at bmsi,jpmc,karachi. methods: ninety healthy adult albino rats were included in the study and divided equally into 3 groups for 12 weeks. group-a was taken as control. group-b received levothyroxine orally,daily in a dose of 8 μgm /100 g bw for 12 weeks to induce experimental hyperthyroidism. group c was given levothyroxine orally in the above mentioned dose as well as melatonin in drinking water daily in a dose of 10 mg/100 g bw. results: melatonin significantly restored the thickness of bone cortex in the shaft of femur in group b without affecting the levels of tsh in hyperthyroid state. conclusion: melatonin canpromote bone formation and prevent bone resorption during hyperthyroidism.