Comparison between Serum hsCRP and LDL Cholesterol as a Predictor for Ischemic Heart Disease

Background: acute myocardial infarction is major cause of morbidity & mortality in world and atherosclerosis is one of major causes of cardiovascular disease. low-density lipoprotein-c (ldl-c) is independent risk factor of atherosclerosis and has been used to predict the risk of ihd. but high sensitivity c-reactive protein (hscrp) is more powerful inflammatory marker and can be used to predict future cardiovascular event. aim: to investigate whether hscrp or ldl-c is a better predictor of future ischemic heart disease (ihd). methods: hundred and two patients of myocardial infarction and ninety eight controls were studied for hscrp and ldl-c over a period of 2 years in pathology department at quaid-e-azam medical collage bahwalpur. results: the concentration of hscrp in serum in cases of ihd is significantly higher (3.34±0.73 than controls (0.67 ± 0.18) (p < 0.0001) but differences in concentration of serum ldl-cholesterol between ihd cases and controls are not significant (p>0.05). conclusion: we conclude that the serum hscrp is a better marker for risk of ischemic heart disease.