Correlation of interleukin-10 with glasgow coma scale in patients of stroke

Background: interleukin-10 is an anti-inflammatory cytokine that has multiple functions. its anti-inflammatory properties suggest its neuro-protective role in stroke patients. glasgow coma scale (gcs) is a clinical scoring system to evaluate the severity of brain damage in stroke. in the present study,we tried to find out any correlation between a clinical assessment tool and a related biochemical parameter in patients of stroke. methods: a total number of 120 consecutive patients of stroke were included in this study. they were subdivided on the basis of their blood pressure at admission into hypertensive (n=60) and non-hypertensive (n=60) groups. clinical assessment of severity of brain damage due to stroke was evaluated by using gcs on admission. at the same time,a blood sample was taken to estimate plasma level of il-10. correlation coefficient was calculated between gcs and il-10 levels to find out any relationship between the two. results: in the hypertensive group,mean±sd of il-10was 3.8±9.3pg/ml and of gcs was 10.98±3.55. in the non-hypertensive group,mean±sd of il-10 was 5.4±13.7pg/ml and of gcs was 10.45±4.01. correlation coefficient between il-10 &gcs of all stroke pts was-0.305 with p-value<0.001. conclusion: it is concluded that il-10 plays a protective role in patients of stroke.