Effects of gluten-free diet on immunological assays in children with celiac disease

Aim: effects of gluten-free diet on immunological assays in children with celiac disease aging 2-15 years. study design: descriptive observational study. setting: department of paediatric ghurki trust teaching hospital,lahore. sample size: 50 patients. methodology: total 50 cases were included. the immunological assays and proximal bowel biopsy were performed in every case. results noted on proforma and analyzed. results: majority of biopsy proven cases responded to gluten free diet 80% and showed 73.3% improvement of anti gliadin (iga) and 60.7% (igg) while tissue transglutaminase iga and igg are improved in 85.3% after 4-6 months of treatment. conclusion: there is gradual decline of titers of serum antigliadin and anti tissue transglutaminase. patients with poor compliance to treatment were mostly early teenagers in whom disease remained unresolved.