Comparison of side effects of tolterodine and solifenacinsucinate in patients with urinary incontinence

Background: overactive bladder syndrome is a common symptom complex that affects millions of people worldwide,with an increasing prevalence with increased age. the ideal anti muscurinic agent should effectively relieve the symptoms of oab,with the minimum of side effects; it should be available as a once-daily sustained release formulation. aim: to compare the side effects of tolterodine & solifenacin succinate in pts with urinary incontinence. study design: randomized controlled trial setting: department of obstetrics and gynecology,lady willington hospital lahore duration: 09th october 2013 to 8th april 2014. methods: an informed consent was obtained. patients were randomly divided (using lottery method) in both study groups. in group-a patients were treated with tolterodine (4mg) and in group-b patients were treated with solifenacin succinate (5mg). all information including side effects (as per operational definitions) were collected post treatment and follow up at 3 months by the researcher herself. results: mean age of all 830 patients was 57.34±11.54 years. in group-a there were 123(29.64%) patients who had dry mouth and in group-b there were 101(24.34%) patients told that they had dry mouth. in group-a there were 123(29.64%) patients who had dry mouth and in group-b there were 101(24.34%) patients told that they had dry mouth. it was observed that more patients had dry mouth in group-a as compared to that of in group-b. conclusion: this study found that solifenacin succinate (5mg) had significantly higher occurrence of constipation as compared to tolterodine (4mg). i.e.,9.88% vs. 5.06%. while occurrence of dry mouth was also higher but not significant in solifenacin succinate. these results showed that difference in side effects between tolterodine and solifenacin succinate in patients with urinary incontinence.