Antimullerian hormone as a marker of ovarian reserve

Aim: to determine the predictive value of antimullerian hormone as a marker for ovarian reserve and compare it to other markers such as age,fsh and antral follicle count. methods: a prospective study carried out at ivf centre from 1st january,2014 to 30th december 2014. it included 50 patients who were enrolled for ivf/icsi treatment. all of these patients underwent hormonal profile such as fsh,lh. amh and estradiol level on 2ndday of menses and transvagainal u.s.g on 5th-8th day of cycle for antral follicle,count of 2-5mm in size. these patients received controlled ovarian stimulation by gonadotrophins. dose was decided according to age and bmi.primary outcomes measure was number of oocyte retrieved. result: while good responders' achieved higher estradiol level (mean 7103(2594) as compared to group b 5041(3791) and dose of gonadotrophins required was less in group a 2718(2187) as compared to group b 2804(1368) age was comparable 34.1 in both groups. this study did not depicted age and fsh to have any significant correlation with ovarian response. but antral follicle count and amh emerged as predictor of ovarian reserve significantly p=.002 and p.000 respectively. amh is even better predictor of ovarian response. amh had 97% sensitivity and 41.6% specificity in predicting the response conclusion:amh is good predictor of ovarian reserve with high sensitivity. it helps in individualizing the dose for ovarian stimulation and can effectively identify women who will not respond to ovarian stimulation.