Comparison of side effects of solifenacin vs tolteridine in patients with urinary incontinence

Background: urinary incontinence is a distressing condition affecting million of women all over the world and prevalence is on rise in old age. anti-muscaranic agents are used to treat this disease. effective treatment modality with minimum side effect remains a major challenge in these women. aim: to compare the side effects of tolterodine and solifenacin succinate in patients with urinary incontinence. study design: randomized controlled trial sampling technique: non probability purposive sampling methods: 830 women,aged 35-90 years presenting in opd of sharif medic and dental college /smch fulfilling the inclusion criteria were randomly treated with solifenacin succinate 5mg (group-a) and tolterodine 4mg (group b) in duration of 5 years. demographic characters including age,duration and pattern of urinary complaints were inquired. both groups were followed for 3 months. all information analyzed using spss version 18. frequency of side effects were noted in both groups and was assessed using chi-square test and p value <0.05. mean± sd calculated for quantitative data like age and qualitative data like side effects (dry mouth,constipation). results: mean age of patients was 57.34±11.54 years. dry mouth was observed in 123(29.64%) patients in group-a and 101(24.34%) in group-b (p-value 0.085),while constipation was observed in 41(9.88%) patients in group-a and 21(5.96%) patients in group b. (p-value 0.000) conclusion: solifenacin succinate (5mg) had significantly higher occurrence of constipation as compared to tolterodine (4mg) while occurrence of dry mouth was also higher but not significant. these results showed that difference in side effects between tolterodine and solifenacin succinate in patients with urinary incontinence.