Serum resistin levels in patients of hypertension and coronary artery disease

Background: hypertension is a chronic disease which affects different body organs,especially heart and blood vessels leading to coronary artery disease. resistin,secreted from inflammatory blood cells,is a cysteine rich polypeptide and is related to obesity,inflammation and atherosclerosis in humans. aim: to determine and compare serum resistin levels in normotensives,newly diagnosed patients of hypertension,stable angina pectoris and myocardial infarction with hypertension. methodology: in this comparative study,eighty subjects both male and female,within the age limit of 35 - 55 yrs were divided into four equal groups i.e. normotensives,newly diagnosed cases of hypertension,stable angina pectoris and myocardial infarction,both with hypertension. serum resistin was determined by enzyme linked immunosorbent assay in their fasting blood samples and compared according to appropriate statistical techniques using spss 17.0. results: serum resistin levels were significantly raised in patients of hypertension and coronary artery disease as compared to normotensives. resistin levels were found progressively raised with increasing severity of cardiac disease. conclusions: the increase in serum resistin levels in patients of hypertension and coronary artery disease may reveal a possible involvement in induction and progress of pathological changes in heart and blood vessels.