Comparison of intravaginal misoprostol (PGE1) with dinoprose (PGE2) for termination of 2nd trimester pregnancy

Aim: to compare the effectiveness and side effects of intravaginal misoprostol(pge1) with dinoprostone (pge2) for labour induction in second trimester termination of pregnancy. design: prospective experimental study. setting: lady aitchison hospital,lahore. duration: for a period of eight months from july 2014 to february 2015. methods: hundred women with mid-trimester foetal loss or congenitally malformed foetus on ultrasonography were selected. these women were randomized to receive either intravaginal misoprostol or dinoprostone. main outcome measures were efficacy and safety in terms of abortion-induction interval and side effects. induction was considered successful where abortion was achieved. results: the average induction-abortion interval in the misoprostol group was 15.05 hours and successful abortion was achieved in 80% (40/50) of cases whereas in pge2 group 48% (24/50) aborted in the same time interval (15.05 hours). the rate of incomplete abortion requiring evacuation and curettage was 20% (10/50) in misoprostol group and 52% (26/50) in pge2 group. in pge1 group frequently observed side effects were chills 12(24%),fever 7(14%),abd. pain occurred in 20(40%) conclusion: the less expulsion time,higher rate of complete miscarriage and minimal side effect seen in misoprostol group in our study showed that vaginal misoprostol is superior as a labour inducing agent in comparison to pge2 dinoprostone) for termination of 2nd trimester of pregnancy.