Histological effects of ribavirin on adult ovary of albino rat

The present study was planned to evaluate the histological effects of ribavirin on adult ovary of albino rat in doses of 20,100,200mg/kg orally for five consecutive days of estrous cycle at interval of 24 hrs. estrous cycle was measured by vaginal smear method. the ovaries were processed for histopathological analysis on day 14 after the last exposure. the histological parameters were capsule,primordial follicle,secondary follicle,diameter of graafian follicle and secondary oocyte. data was analysed by anova and tukey's test for statistically significant difference. capsule was of same nature in all groups. primordial follicles,secondary follicles were significantly atrophied in high dose groups i.e.,100 and 200mg/kg as compared to control. post hoc analysis revealed significantly low diameter of graafian follicle and diameter of secondary oocyte in high dose groups i.e.,100 and 200mg/kg as compared to control. conclusion: ribavirin administration in adult female rat showed significant harmful effects on ovary,and these gonadotoxic effects of ribavirin may cause infertility in females during reproductive period. © 2016,lahore medical and dental college. all rights reserved.