Comparison of efficacy between intravenous ondansetron and intravenous lidocaine on propofol induced vascular pain

Aim: to compare the effects of intravenous ondansetron and intravenous lidocaine on reduction of propofol induced vascular pain. methods: this randomized controlled trial was conducted at department of anaesthesia,combined military hospital,bahawalpur from november 2015 to may 2016. total 700 patients undergoing elective surgeries,having age 18-55 years of both sexes and having asa grade i & ii were selected for this study. group a received injection lidocaine plain 2% (2ml) while group b received ondansetron 4 mg (2 ml) at the time of induction of anesthesia. results: age of the patients ranged between 18-55 years. mean age of the patients was 33.1±9.1 years and 32.6±8.9 years in group-a and group-b,respectively. in group-a,233 (66.6%) patients and in group-b 239 (68.3%) patients were males while 117 patients (33.4%) in group-a and 111 patients (31.7%) in group-b were females. pain reduction was observed in 224 patients (64.0%) of group-a while in group-b pain reduction was reported by 266 patients (76.0%). conclusion: in conclusion,lidocaine pretreatment provides a simple and safe method of reducing the incidence of pain on injection of propofol and avoiding the administration of other drugs that may be undesirable in certain circumstances. © 2016,lahore medical and dental college. all rights reserved.