Glucose tolerance and serum total triglycerides status in diabetic related pregnant women

Background: glucose plasma tolerance,and serum total triglycerides status deviate upward significantly from normal in pregnant women,who are not themselves known cases of diabetes mellitus [dm],but their first degree relatives [parents,off springs and siblings] do have established dm. the possible link between this relation in genetic lineage and expression of that under the stress of pregnancy [usually around 24 weeks] is widely accepted in medical literature,and this may be a physiological variable according to age and parity of pregnant women. aim: to know this relationship of genes of dm with their expression under physiological stress of pregnancy in non-diabetic pregnant women having probable propensity due to their first degree genetic relatives of already diagnosed dm. methods: total 240 subjects,divided age wise into four groups,with raised blood sugar fasting [bsf] and serum total triglycerides compared with 50 controls. results: insignificant graduated group wise increment in serum total triglycerides [r=0.122,p>0.05] revealed,but the change in bsf was in line with change in serum total triglycerides. conclusion: deviated bsf and serum total triglycerides levels incline from upper normal cut off values may be an indicator of expression of genes of dm in pregnant women,whose first degree relatives are known patients of dm. © 2016,lahore medical and dental college. all rights reserved.