The significance of proteinuria and its associations in patients having acute renal failure

Aim: to determine the significance of proteinuria and its associations in pts having acute renal failure. method: the type of study is a prospective observational study conducted for a period of three months from january 2014 to march 2014,at a tertiary care centre in karachi pakistan. a total of n= 40 patients who presented to our department with acute renal failure or acute chronic renal failure were included in the study. proteinuria was analyzed with gel electrophoresis in the patients and its predictive value for requirement of renal replacement therapy was noted. results: a total of n= 40 patients were included in the study,having a mean age of 58.6 +/- 27 years and a male to female ratio of 24 : 16. mortality of patients was 15(37.5%),the non survivor population was in critical condition at the time of referral having an apache ii score of 29 +/- 5,they also had lower values for baseline creatinine and a higher tubular to glomerular ratio which points towards acute tubular necrosis. among those who had survived 25(62.5%) a total of 7(17.5%) patients were those who did not recover and 19(47.5%) were those who recovered and returned towards normal renal functioning. those who did not recovered had increased levels of tubular proteinuria and went into end stage renal disease. conclusion: according to the results from our study the gel electrophoresis analysis for proteinuria is a cost effective and reliable method,when it comes to determining the tubular or glomerular proteinuria in patients with acute renal failure requiring renal replacement therapy in the intensive care unit. presence of tubular proteinuria correlates with duration of dialysis support and the mortality rate,and the presence of glomerular proteinuria indicates glomerular damage and its severity. � 2016,lahore medical and dental college. all rights reserved.