Patterns of spirometry in patients of chronic Hepatitis C while on conventional interferon & ribavirin treatment

Background: serious pulmonary toxicities of combination interferon therapy have been reported in literature. aim: to monitor the pulmonary function test while on interferon therapy. methods: single center study was done on 90 patients taking conventional interferon therapy. spirometry of these patients were done who were at baseline (n=30),2nd month (n=30) and 6th month of treatment (n=30) results: significant obstructive pattern is observed at 6 months of therapy as compared to baseline in patients of chronic hepatitis c while on conventional therapy. conclusion: all patients with chronic hepatitis c infection along with respiratory disease must have the monitoring of respiratory function test before and during the course of therapy.