Correlation of Serum Visfatin and Interleukin-6 in Obese and Non-Obese Male patients of Coronary Artery Disease (CAD)

Background: adipose tissue is an active endocrine secretory organ that produces different series of biologically active factors,the adipocytokines namely visfatin and interleukin-6 (il-6). il-6 is proinflammatory mediator in atherosclerosis which is released by macrophages. visfatin is also a cytokine which function as growth factor for vascular smooth muscle cells,a hallmark of atherosclerosis and anti apoptotic effects on localized neutrophils. aim: to investigate the correlation of these adipocytokines in cad to find a link between serum visfatin and il-6 in atherosclerosis leading to cad. methods: it was cross sectional analytical study conducted in punjab institute of cardiology,lahore from july 2013 to december 2013. in this study forty male subjects with angiographically proven stable symptomatic cad further divided into 20 non obese of same age and waist circumference with cad and 20 obese male patients with cad. serum visfatin and interleukin-6 levels were assayed by enzyme-linked immunosorbent assay (elisa). the collected data was entered and analyzed using spss version 20. data normality was explored by using the shapiro wilk's test. spearman rho correlation was used to correlate serum visfatin and interleukin-6 for non normally distributed data. a p-value of ≤0.05 was considered statistically significant. results: significant positive correlation between serum visfatin and serum interleukin-6 was found in cad in obese and non obese male patients (n=40) (rho=0.680,p=0.000). significant correlation persist when partial correlation was applied after controlling waist circumference and body mass index. conclusion: strong positive correlation between serum visfatin and il-6 in male patients with cad suggest that circulating serum visfatin may be related with proinflammatory effects in cad.