Interaction between serum Thrombomodulin and serum CRP levels in predicting ischemic heart disease: A story in reverse direction

Aim: to find out the association between serum thrombomodulin (tm) & serum c-reactive protein (crp) in identifying individuals at risk of ischemic heart disease (ihd) in pakistani population methods: this cross sectional study was conducted on population of karachi,pakistan. a total of 96 subjects were randomly selected and were divided into 3 groups i.e.,group a= (control group),group b= (myocardial infarction [mi] patients),group c (unstable angina [ua] patients). each group consists of 32 subjects/patients respectively. the diagnoses were made on the basis of history,e.c.g. & serum troponin i levels. serum thrombomodulin (tm),serum c reactive protein (crp) were determined by elisa kit methods. independent sample t-testwas conducted for comparison of serum thrombomodulin (tm) level & serum c reactive protein (crp) levels between these groups. pearson correlation co-efficient were used to calculate the co relation between serum thrombomodulin (tm) and serum c reactive protein (crp) levels results: serum thrombomodulin levels were significantly higher in control group (p-value 0.00),whereas,serum crp,bmi,blood pressure,serum l.d.l. cholesterol and serum total cholesterol levels were significantly higher in diseased group. conclusion: the present study suggests that serum tm levels were high in control group in comparison with diseased group,whereas serum crp levels were high in diseased group,suggesting inverse relationship between serum tm & crp in predicting ischemic heart disease.