Effect of semen characteristics on outcome of intra uterine insemination

Aim: to determine the influence of various sperm parameters inseminated on the outcome of intra uterine insemination (iui) in patients undergoing ovarian stimulation with clomiphene citrate followed by hcg and to assess the likelihood of iui success as a function of normal motile sperm inseminated (nmsi) and of the percentage of morphologically normal spermatozoa,assessed after sperm preparation. study design: quasi experimental study. place of study: the study was conducted at surgimed hospital infertility centre lahore from january 2010 to december 2016. methods: a total of 600 infertile couples underwent 800 infertility treatment cycles. after ovulation induction and follicle monitoring human chorionic gonadotrophin (hcg) was given and iui done. the initial sperm count and concentration,sperm motility,pre and post wash processed sperm count and concentration,fast motile sperm percentage,total motile sperm (tms) count and sperm morphology were analyzed. the impact of preprocessing and post processing sperm parameters on pregnancy outcome after iui was evaluated. results: there was a trend towards an increasing percent of conception with increasing tms count inseminated. total sperm count,percent motility and percent of fast motile sperm were independent prognostic factors of fertility. patients with sperm motility >or =30% had pregnancy rate of 13% whereas pts with low motile counts had significantly less (p<0.005) pregnancy rates. conclusion: sperm motility is a major determinant of pregnancy out come following iui.