Comparison of mean duration of post-operative analgesia in laparoscopic cholecystectomy patients receiving intra-peritoneal bupivacaine versus bupivacaine plus buprenorphine

Aim: to compare the mean duration of post-operative analgesia in laparoscopic cholecystectomy patients receiving intraperitoneal bupivacaine versus bupivacaine plus buprenorphine. design: it was a randomized controlled trial. place and duration of study: this study was conducted at the department of surgery,unit-i,sir ganga ram hospital,lahore over 6 months period from july 2015 through december 2015. methods: this study was a blend of both the genders with 80 patients having age between 20-70 years undergoing laparoscopic cholecystectomy under general anesthesia. two treatment groups were made by dividing these patients equally. patients of group-a (n=40) received intra-peritoneal bupivacaine alone while patients of group-b (n=40) received intra-peritoneal bupivacaine + buprenorphine. outcome variable was post-operative analgesia duration which was noted and compared between the two groups. an informed written consent was taken from all the patients. results: the patients had a mean age of 47.56±9.24 years. the sample included 24(30%) male and 56(70%) female patients with a female to male ratio of 2.3:1. both the study groups had no significant difference in reference with age groups (p=1.000),gender (p=0.626) distribution and mean age (p=0.971). the mean duration of post-operative analgesia was significantly longer with intra-peritoneal bupivacaine+buprenorphine (9.43±1.08 hrs. vs. 3.05±1.18 hrs; p=0.000) as compared to intra-peritoneal bupivacaine alone. this difference was significant across all age and gender groups. conclusion: the mean duration of post-operative analgesia was long significantly with intra-peritoneal bupivacaine+buprenorphine (9.43±1.08 hrs. vs. 3.05±1.18 hrs; p=0.000) as compared to intra-peritoneal bupivacaine alone regardless of patient's age and gender.