Impairments in renal functions in relation with obesity

Background obesity is recently acknowledged as an important independent risk factor for kidney disease,in which epidemiological evidence played a crucial role. this risk is probably explained by intracellular lipid accumulation in the kidney. life style factors such as physical activity and diet play a role in the development of kidney disease in several stages. impaired renal function is strongly related to cardiovascular disease and mortality. one in every 200 adults suffers from chronic kidney disease,and with growing obesity epidemic,this is likely to increase. this means that since kidney disease takes a long time to develop,pre-clinical kidney dysfunction is much more prevalent,and estimates in the general population ranges from 5 to 11%. methods: the present study is based on a total of 75 subjects comprising 45 patients with renal failure with or without obesity and metabolic syndrome. patients with acute renal infection,nephrolithiasis or specific cardiovascular disease were excluded from study. serum creatinine,urea,blood sugar random,(estimated glomerular filtration rate) egfr,hemoglobin,calcium,and phosphate were investigated. results: the mean egfr level in 45 patients with renal disease were markedly higher than those of controls,no significant difference was shown between levels of obese without (renal disease) rd and of control subjects. serum creatinine was higher in patients with renal disease. the level in obese renal patients was not significantly different from those with non obese patients with renal failure. conclusion: our results based on measurement of various peripheral markers of ckd,failed to suggest a further aggravation of renal dysfunction due to obesity or in the presence of metabolic syndrome,in this cohort of patients.