Contrast induced renal dysfunction in patients undergoing percutanous coronary intervention

Background: contrast-induced nephropathy remains a common complication of radiographic procedures. however,ionic contrast media cause more renal insufficiency than non ionic one due having low osmolality and chemotoxicity. aim: to examine the contrast induced renal dysfunction in patients undergoing percutaneous coronary intervention. methods: a prospective,single-center,randomized trial conducted for six moths,between january & july 2007,of 100 patients. serum creatinine levels were measured at baseline and 1 and 2 days after contrast. patients received median dose of non ionic contrast 101±16.64 ml and 110±12.9 ml of ionic contrast. results: there were no significant group differences in age,but significant difference was seen in sex (p=0.01). the incidence of renal insufficiency (ri) was more in patients suffering from and hypertension and diabetes mellitus. out of 100 (78 male and 22 female) patients only 18(18%) developed ri. out of 78 male patients,12(15%) male and of 22 female patients,6(27%) showed ri. conclusion: non ionic contrast media is safe to use for angiography in spite of predisposing factors like hypertension and diabetes mellitus.