Helicobacter Pylori-induced chronic inflammation leading to gastric mucosal erosions in Pakistani citizens

Aim: to know the underlying processes by this causative organism inflicts damage to the mucosa of the stomach. methods: this descriptive cross sectional reseach work was conducted on three hundred individuals with clinical presentation of gastropathy who report in opds of quetta,rahim yar khan and sahiwal from march 2014 to july 2016. from eighteen patients we got gastric biopsy specimens with chronic gastropathy resulting from helicobacter pylori infection. results: the analysis of gastric biopsy depicted elevated protein complex that controls transcription of dna,cytokines production and cell survival (nf-kb) with superoxide dismutase activities enhanced display of poly adp ribose polymerase-1 (parp-1) and a marker for dna damage or dna damage response (h2ax). after recommended regime of drugs to eradicate helicobacter pylori,analysis of gastric biopsy showed standard parameters of nf-kb with superoxide dismutase activities enhanced display of parp-1 and gh2ax. that proved possible cause of gastropathy may be oxidative dna insult and elevated parameters of poly adp ribosepolymerase-1 (parp-1). conclusion: this current research work recommend that in a situation where there is insult to lining epithelium of stomach,underlying cause is non-homologous end joining (nhej) and (ros) reactive oxygen species which inflicts unusual telomere end joining resulting to telomere shortening treatment.