Recoverability of reproductive system in patients with concomitant hyperandrogenism

Aim: to find out whether the influence of hyperandrogenic states on women's reproductive system depend on the source of the hyperandrogenism. design: the study was carried out from 2003 to 2010. 105 women were examined and treated in the study. as criteria of participants' inclusion,the clinical symptoms of hyperandrogenism were regarded: hirsutism,acne,and other signs of androgen-dependent dermopathy. at the next stage,laboratory criteria of hyperandrogenism were assessed: concentrations of total and free testosterone,androstenedione,dihydrotestosterone,and other hormones in the course of the menstrual cycle. methods: the hormonal panel tests were performed in the course of the menstrual cycle,assessing the level of secretion of peptide and steroid sex hormones. in addition to measuring quantitative indicators of these hormones,the qualitative indicators of such relation as progesterone/estradiol,total testosterone/estradiol,dihydrotestosterone/estradiol,estradiol/free testosterone,luteinizing hormone/follicle-stimulating hormone were considered. in order to exclude the cases of thyroid gland pathology,the levels of thyroid gland hormones in blood were tested. all the patients were examined for the non-hormonal homeostasis to reveal disorders of lipid storage and carbohydrate metabolism. the obtained data were statistically processed involving parametric and non-parametric methods. results: adrenic hyperandrogenism exerts a negative effect on the processes of folliculogenesis,while ovarian hyperandrogenism is preconditioned by the anovulation state and can be stopped virtually completely with recovery of ovulation. conclusion: anovulation state causes an increase in the level of the main androgens,and the luteal phase deficiency is a consequence of the negative impact of hyperandrogenism. individual pathogenesis-based therapy,considering the condition of the reproductive system,allows recovering ovulation and securing pregnancy against a background of normalization of androgen metabolism and other indicators of the functioning of the reproductive system.