Comparison between topiramate and Sodium valproate efficacy in the treatment of migraine

Background: migraine is a headache,a neurological disorder associated with significant impairment in the quality of life in patients as well as disability. topiramate (tpm) and sodium valproate are used as preventive therapies for migraine. studies comparing the efficacy of these agents are scarce. aim: to compare the efficacy of topiramate with sodium valproate in terms of reduction of frequency in migraine in patients with migraine. methods: this randomized controlled trial study was carried at mu-iv,dhq hospital,faisalabad over a period of six months from 1st january 2017 to 30th june 2017 and comprised 90 cases. the patients were divided in two groups; group a (sodium valproate) and group b (topiromate). each group comprised equal number of cases. results: in our study groups a and b,20(44%0) and 18(40%) cases in were found to be between 12-40 years of age,compared to 25(55.5%) and 27(60%) aged 41-55 respectively. mean age was similar in both groups with 39.55±9.29 in a vs 42.11±8.91 years in b. 11(24.44%) in group-a and 14(31.11%) in group-b were male while 34(75.56%) in group-a and 31(68.89%) in group-b were females. comparison of efficacy of topiramate with sodium valproate in terms of reduction of frequency in migraine in patients with migraine showed efficacy of 29(64.44%) in group-a and 16(35.56%) in group-b,p value was 0.006 which shows a significant difference between the two groups. conclusion: sodium valproate as compared to topiramate is significantly better for reduction of frequency in migraine in patients with migraine.