A study to evaluate α-methylacyl Co-A racemase expression in hyperplasia and different grades of adenocarcinoma of prostate

Aim: to evaluate α-methylacyl co-a racemase (amacr) expression pattern in hyperplasia and different grades of adenocarcinoma of prostate. design: descriptive study. place post-graduate medical institute,lahore. method: one hundred biopsies were taken from lahore general hospital. after haematoxylin and eosin staining,amacr immunostaining was done. results: total one hundred biopsies (50 cases each of hyperplasia and carcinoma) were included in present study. age comparison in hyperplasia and carcinoma cases showed statically significant (p=0.001) difference. on histological examination,all carcinoma cases were graded using gleason's scoring system. none of the cases were well differentiated,23(46%) were poorly differentiated and 27(54%) showed moderate differentiation. carcinoma cases mostly presented with high grade cancers. after diagnosing on h&e,all the cases were immunostained with amacr. all hyperplasia cases showed no reactivity while all carcinoma cases expressed amacr. conclusion: it was observed that all cases of hyperplasia were negative whereas all carcinoma cases showed positive amacr expression. it was concluded that amacr is a useful immunomarker for diagnosing challenging cases of prostatic adenocarcinoma.