Effect of Striped Snakehead fish (ophiocephalusstriatus) extract supplement pills compared to human albumin infusion on Albumin Serum,Lipid Profile,Malondialdehyde and IL-8 serum level on Nephrotic Syndrome

Aim. to determine the effect of striped snakehead fish extract supplement pills compared to human albumin infusion on albumin serum,lipid profile,malondialdehyde (mda),interleukin-8 (il-8),and body weight in ns. method: randomized controlled trial of children with ns aged 2 -14 years old was conducted in rsup dr. kariadi hospital and other hospitals around semarang from april 2012 to february 2013. subjects were divided in group i (received the supplement pills 75 mg/8 hours for 21 days and human albumin infusion 0.5 g/kgbw) and group ii (received human albumin infusion only). protein,lipid profile,mda,il-8,diet intake,and body weight were analyzed. result: eighteen patients in group i and 17 in group ii were compared. increased in albumin serum level were 2,2±0,64 g/dl vs 0,9±0,96 g/dl (p=0,001),mean decreased in total cholesterol were 199,3±101,82 mg/dl vs83,1±83,94 mg/dl (p=0,002),decreased in ldl were 159±79,11mg/dlvs 88,9±88,66 mg/dl (p=0,02),mean of weight loss were 1,4±0,61 kgvs0,7±0,6kg (p=0,003) respectively. decreased in mda level in group i was 2.4±1.12. no difference of il-8 serum in both groups. conclusion: in pediatric ns,supplementation with striped snakehead fish extract pills effectively increase albumin serum,decrease total cholesterol,ldl,mda serum,and edema through weight loss,but not decrease il-8 serum.