Characterization of Oryza sativa Rad51 for Phosphorylation using in silico Approach

Repair of dna double strand breaks by homology mediated dna repair is crucial for accurate transmission of genetic information to the daughter cells or organisms. rad51 is central to recombination reaction whose regulation is attributed to different proteins. moreover,post-translational modifications such as phosphorylation also play a part to modulate its activity. in the present study,we have identified highly important phosphorylation sites in rad51,a eukaryotic orthologue from oryza sativa indica (osind-rad51). overall the protein has been found highly conserved among different organisms especially involving residues predicted for phosphorylation. therefore,it is tempting to speculate an important role of these phosphorylation sites in regulating recombination via rad51. in future,these studies will have an impact in breast cancer control.