Effect of β-Thalassemia on Hematological and Biochemical Profiles of Female Patients

Thalassemia is one of the most common monogenic disorders all around the world. the disease alters the hematological and biochemical parameters of the patients important in future care of the patient for plan of blood transfusion,iron chelation therapy and other life saving strategies. the study describes socio-economic,hematological and biochemical profiles of female thalassemic patients. fifty female thalassemic patients were selected from different thalassemic centers in punjab (pakistan). the patients had mean age 14.6±3.09 years and body weight 35.7±10.4 kg. siblings of 82% patients had at least one type of thalassemia as the consanguinity was 62%. most of the patients belonged to lower class 58%,spleenectomy 60% and delay in puberty and secondary sex characters 82%. the mean±sd values of cbcs were: wbcs 35×103 ± 10×103/μl,neutrophils 32 ± 14.8%,hematocrit 28 ± 4%,mchc 31±5 g/dl,rbcs 3×106±0.6×106/μl,hb 8±1 g/dl,platelet 322×103 ± 65×103/μl,rdw 43% ± 11% and esr 50±11 mm/h. the biochemical parameters were: alanine transaminase 119±10 u/l,aspartate transaminase 77±23 u/l,alkaline phosphatase 366±150 u/l,triglycerides 108±38 mg/dl,cholesterol 104±35 mg/dl,total protein 5.4±2.1 g/dl,albumin 4.5±1 g/dl,serum creatinine 3.2±1 mg/dl,urea 3.5±1.3 mg/dl,total bilirubin 2.4±.3 mg/dl and serum ferritin 3255±1594 μg/l. both cbc and biochemical parameters of the patients significantly deviated from the normal values (p < 0.05). the altered hematological and biochemical parameters may change iron chelation response in the patients. therefore,cbc and biochemical parameters should be considered for future plan of transfusion and iron chelation therapy.