Saccharum officinarum derived mid molecular mass glycoproteins as native brms in chickens

Present study describes the biological response modifying (brm) activities of saccharum officinarum (sugar cane) derived mid molecular mass glycoproteins (mmmgs) in broiler chickens. mmmgs were isolated from sugar cane juice by size exclusion chromatography. the electrophoretic analysis of mmmgs by using experiontm automated electrophoresis station showed the presence of thirteen different glycoprotein fractions with molecular weights ranging from 20.16 to 72.06 kda in the isolated sample. brm activities of mmmgs were evaluated in terms of cellular and humoral immune responses; and production performance. findings of present study revealed that mmmgs significantly enhanced (p<0.05) the in vivo and in vitro lymphoblastogenic responses to phytohaemagglutinin-p and concanavalin-a,respectively in chickens. significantly elevated b-cell mediated immune response in terms of antibody titres to sheep erythrocytes,newcastle disease and infectious bursal disease vaccines (p<0.05) in mmmgs administered chickens were also detected. lymphoid organ-body weight ratios were statistically similar (p>0.05) in both mmmgs administered and control groups. production performance was determined in terms of feed conversion ratios that was significantly improved (p<0.05) in chickens administered with mmmgs as compared to those of control group. in conclusion,mmmgs demonstrated immunostimulatory potential in broiler chickens and can be used as native brms in chickens to boost up their immune responses and production performance.