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Immunity to visceral leishmaniasis using genetically defined live-attenuated parasites
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نویسنده
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selvapandiyan a. ,dey r. ,gannavaram s. ,lakhal-naouar i. ,duncan r. ,salotra p. ,nakhasi h.l.
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منبع
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journal of tropical medicine - 2012 - شماره : 0
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چکیده
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Leishmaniasis is a protozoan parasitic disease endemic to the tropical and subtropical regions of the world,with three major clinical forms,self-healing cutaneous leishmaniasis (cl),mucocutaneous leishmaniasis (mcl),and visceral leishmaniasis (vl). drug treatments are expensive and often result in the development of drug resistance. no vaccine is available against leishmaniasis. subunit leishmania vaccine immunization in animal models has shown some efficacy but little or none in humans. however,individuals who recover from natural infection are protected from reinfection and develop life-long protection,suggesting that infection may be a prerequisite for immunological memory. thus,genetically altered live-attenuated parasites with controlled infectivity could achieve such memory. in this paper,we discuss development and characteristics of genetically altered,live-attenuated leishmania donovani parasites and their possible use as vaccine candidates against vl. in addition,we discuss the challenges and other considerations in the use of live-attenuated parasites. © 2012 angamuthu selvapandiyan et al.
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آدرس
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institute of molecular medicine,254 okhla industrial estate phase iii, India, division of emerging and transfusion transmitted diseases office of blood research,review center for biologics evaluation and research food and drug administration,bethesda, United States, division of emerging and transfusion transmitted diseases office of blood research,review center for biologics evaluation and research food and drug administration,bethesda, United States, division of emerging and transfusion transmitted diseases office of blood research,review center for biologics evaluation and research food and drug administration,bethesda, United States, division of emerging and transfusion transmitted diseases office of blood research,review center for biologics evaluation and research food and drug administration,bethesda, United States, institute of pathology (indian council of medical research),safdarjung hospital, United States, division of emerging and transfusion transmitted diseases office of blood research,review center for biologics evaluation and research food and drug administration,bethesda, United States
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Authors
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