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   The host genetic diversity in malaria infection  
   
نویسنده de mendonça v.r.r. ,goncalves m.s. ,barral-netto m.
منبع journal of tropical medicine - 2012 - شماره : 0
چکیده    Populations exposed to plasmodium infection develop genetic mechanisms of protection against severe disease. the clinical manifestation of malaria results primarily from the lysis of infected erythrocytes and subsequent immune and inflammatory responses. herein,we review the genetic alterations associated with erythrocytes or mediators of the immune system,which might influence malaria outcome. moreover,polymorphisms in genes related to molecules involved in mechanisms of cytoadherence and their influence on malaria pathology are also discussed. the results of some studies have suggested that the combinatorial effects of a set of genetic factors in the erythrocyte-immunology pathway might be relevant to host resistance or susceptibility against plasmodium infection. however,these results must be interpreted with caution because of the differences observed in the functionality and frequency of polymorphisms within different populations. with the recent advances in molecular biology techniques,more robust studies with reliable data have been reported,and the results of these studies have identified individual genetic factors for consideration in preventing severe disease and the individual response to treatment. © 2012 vitor r. r. de mendonça et al.
آدرس laboratório integrado de microbiologia e imunorregulaç ão (limi),cpqgm,fiocruz,rua waldemar falcão 121,candeal,40296-710 salvador,ba,brazil,faculdade de medicina,universidade federal da bahia,40296-710 salvador, Brazil, laboratório integrado de microbiologia e imunorregulaç ão (limi),cpqgm,fiocruz,rua waldemar falcão 121,candeal,40296-710 salvador,ba,brazil,faculdade de farmácia,universidade federal da bahia,40296-710 salvador,ba,brazil,instituto de ciência e tecnologia do sangue,campinas, Brazil, laboratório integrado de microbiologia e imunorregulaç ão (limi),cpqgm,fiocruz,rua waldemar falcão 121,candeal,40296-710 salvador,ba,brazil,faculdade de medicina,universidade federal da bahia,40296-710 salvador,ba,brazil,instituto de investigação em imunologia,instituto nacional de ciência e tecnologia,são paulo, Brazil
 
     
   
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