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Mechanisms of phosphine toxicity
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نویسنده
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ebert p.r. ,nath n.s. ,bhattacharya i. ,tuck a.g. ,schlipalius d.i.
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منبع
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journal of toxicology - 2011 - دوره : 2011 - شماره : 0
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چکیده
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Fumigation with phosphine gas is by far the most widely used treatment for the protection of stored grain against insect pests. the development of high-level resistance in insects now threatens its continued use. as there is no suitable chemical to replace phosphine,it is essential to understand the mechanisms of phosphine toxicity to increase the effectiveness of resistance management. because phosphine is such a simple molecule (ph3),the chemistry of phosphorus is central to its toxicity. the elements above and below phosphorus in the periodic table are nitrogen (n) and arsenic (as),which also produce toxic hydrides,namely,nh3 and ash3. the three hydrides cause related symptoms and similar changes to cellular and organismal physiology,including disruption of the sympathetic nervous system,suppressed energy metabolism and toxic changes to the redox state of the cell. we propose that these three effects are interdependent contributors to phosphine toxicity. copyright © 2011 nisa s. nath et al.
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آدرس
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school of biological sciences,university of queensland,st. lucia, Australia, school of biological sciences,university of queensland,st. lucia, Australia, school of biological sciences,university of queensland,st. lucia, Australia, agri-science queensland,department of employment economic development and innovation,ecosciences precinct,gpo box 46,brisbane,qld 4001,australia,cooperative research centre for national plant biosecurity,lpo box 5012,bruce, Australia, agri-science queensland,department of employment economic development and innovation,ecosciences precinct,gpo box 46,brisbane,qld 4001,australia,cooperative research centre for national plant biosecurity,lpo box 5012,bruce, Australia
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Authors
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