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   Production of toxic volatile trimethylbismuth by the intestinal microbiota of mice  
   
نویسنده huber b. ,dammann p. ,krüger c. ,kirsch p. ,bialek b. ,diaz-bone r.a. ,hensel r.
منبع journal of toxicology - 2011 - دوره : 2011 - شماره : 0
چکیده    The biotransformation of metals and metalloids into their volatile methylated derivatives by microbes growing under anaerobic conditions (e.g.,the mammalian intestinal microbiota) plays an important role in spreading these compounds in the environment. in this paper,we could show that the presence of an intact intestinal microbiota of mice provides the conditio sine qua non for the production of these mostly toxic derivatives. to document the indispensible role of the intestinal microbiota in methylating metals and metalloids to volatile derivatives under in vivo conditions,we compared the methylation capability of conventionally raised (conv) and germ-free (gf) b6-mice fed with chow containing colloidal bismuth subcitrate (cbs) as the starting material for the formation of volatile methylated metal(loid)s. permethylated volatile trimethylbismuth ((ch3)3bi) was only detected in the blood of the conventionally raised mice. concomitantly,a higher bismuth concentration was found in organs such as liver,lung,testicles,and brain of the conv mice as compared to those of gf mice (p > 0.01),strongly suggesting a correlation between the intestinal biomethylation of bismuth and its accumulation in mammalian tissues. copyright © 2011 britta huber et al.
آدرس department of microbioloy i,university of duisburg-essen,universitaetsstrabe 2, Germany, central animal laboratory,university hospital essen,hufelandstrabe 55, Germany, central animal laboratory,university hospital essen,hufelandstrabe 55, Germany, animal research center,university of ulm,oberberghof, Germany, department of microbioloy i,university of duisburg-essen,universitaetsstrabe 2, Germany, department of microbioloy i,university of duisburg-essen,universitaetsstrabe 2,45141 essen,germany,instrumental analytical chemistry,university of duisburg-essen,universitaetsstrabe 2, Germany, department of microbioloy i,university of duisburg-essen,universitaetsstrabe 2, Germany
 
     
   
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