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   Toxicological characterization of the inorganic and organic arsenic metabolite Thio- DMA V in cultured human lung cells  
   
نویسنده bartel m. ,ebert f. ,leffers l. ,karst u. ,schwerdtle t.
منبع journal of toxicology - 2011 - دوره : 2011 - شماره : 0
چکیده    We synthesised and toxicologically characterised the arsenic metabolite thiodimethylarsinic acid (thio- dma v). successful synthesis of highly pure thio- dma v was confirmed by state-of-the-art analytical techniques including h 1 -nmr,hplc-ftms,and hplc-icpms. toxicological characterization was carried out in comparison to arsenite and its well-known trivalent and pentavalent methylated metabolites. it comprised cellular bioavailability as well as different cytotoxicity and genotoxicity end points in cultured human a549 lung cells. of all arsenicals investigated,thio- dma v exerted the strongest cytotoxicity. moreover,thio- dma v did not induce dna strand breaks and an increased induction of both micronuclei and multinucleated cells occurred only at beginning cytotoxic concentrations,indicating that thio- dma v does not act via a genotoxic mode of action. finally,to assess potential implications of thio- dma v for human health,further mechanistic studies are urgently necessary to identify the toxic mode of action of this highly toxic,unusual pentavalent organic arsenical. copyright © 2011 marc bartel et al.
آدرس institute of food chemistry,university of muenster,corrensstraße 45, Germany, institute of food chemistry,university of muenster,corrensstraße 45, Germany, institute of food chemistry,university of muenster,corrensstraße 45,48149 muenster,germany,graduate school of chemistry,university of muenster, Germany, institute of inorganic and analytical chemistry,university of muenster,corrensstraße 30, Germany, institute of food chemistry,university of muenster,corrensstraße 45, Germany
 
     
   
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