Shortening the induction delivery interval with prostaglandins: A randomized controlled trial of solo or in combination [prostaglandinler ile indüksiyon-doǧum arali{dotless}ǧi{dotless}ni{dotless}n ki{dotless}salti{dotless}lmasi{dotless}: Tek başi{dotless}na veya kombine olgulari{dotless}n randomize kontrollü karşi{dotless}laşti{dotless}ri{dotless}lmasi{dotless}]

Objective: to compare the efficacy and safety of misoprostol alone with dinoprostone followed by misoprostol,all inserted intravaginally in induction of labor at term and the obstetrical outcome. material and methods: a pilot study comprising 111 primigravidae,>37 gestational weeks with singleton pregnancy in cephalic presentation having an unfavorable bishop score admitted for labor induction,were considered and randomly allocated into two groups. in group i (n=55) with intravaginal 25mcg misoprostol 4 hourly (six doses at the most) and and group ii (n=56),with dinoprostone 0.5mg followed eight hours later by 25mcg misoprostol induction to vaginal delivery time was found to be significantly different,being 14.8 h in group- i and shorter in group-ii with a mean of 11.6 h. vaginal delivery rates within 12 h (groups-i and -ii: 47.2%,as compared to 60.7%,respectively) were found to be higher with dinoprostone-misoprostol induction,as well as vaginal delivery rates in 24 h,80.0% and 91.1%. the need for oxytocin augmentation was more frequent in the misoprostol than in the dinoprostone-misoprostol group,(61.8%,and 39.3%),and all these observations were statistically significant. abnormal foetal heart rate pattern occurred more frequently (18.2%) in group-i in contrast to 5.3% in group-ii,as was the incidence rate of (18.2%) who had passage of meconium in group-i,this rate being significantly different from group-ii having meconium passage in 3 cases,a rate of 5.3%. conclusion: using dinoprostone followed by vaginal misoprostol is safe and effective for induction of labor with less need for oxytocin augmentation and shorter induction delivery interval.