Effects of drospirenone pill in Indian women with polycystic ovary syndrome [Polikistik over sendromlu Hintli kadinlarda drospirenon hapinin etkileri]

Objective: to study the effects of treatment with a drospirenone pill (drsp) (with ethinyl oestradiol,ee) in indian women with polycystic ovary syndrome (pcos). material and methods: fifty-one women with pcos (androgen excess society criteria,2006),with preset inclusion-exclusion criteria,treated with a combination of ee 30 mcg and drsp 3 mg cyclically in the traditional (21+7) regimen,were evaluated at baseline and after six and twelve cycles of treatment. parameters studied were - body mass index (bmi),abdominal circumference (ac),ferriman galwey (fg) score,presence of acne and acanthosis nigricans,serum testosterone,sex hormone binding globulin (shbg),fasting glucose and fasting insulin levels. free androgen index (fai) and glucose: insulin ratio (g: i) were calculated. results: significant improvements in clinical and biochemical hyperandrogenic parameters were found at the two points of study. there were no significant changes in bmi,ac,incidence of acanthosis,or metabolic parameters studied. conclusion: ee/drsp improves hyperandrogenic parameters significantly without affecting the insulin resistance adversely in indian women with pcos. © 2011 by the turkish-german gynecological education and research foundation.